FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB Docking_panel_21Explorer results are being read from this database.
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2 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T10T21
Z46032342
[H]Oc1ccc(C(=O)/C=C\c2ccc3c(c2)OCCO3)cc1
0.922 0.922 1 0.92
Z46032342
O=C(/C=C/c1ccc2c(c1)OCCO2)c1ccc(O)cc1
0.854 0.854 1 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z46032342
[H]Oc1ccc(C(=O)/C=C\c2ccc3c(c2)OCCO3)cc1
T21
native IFP available
T21
dockmulti_91311c650f2e_T21
0.922 1.000 0.777 native_similarity final_rank_score -22.7955 -1.17036 14 8 Pose
Z46032342
O=C(/C=C/c1ccc2c(c1)OCCO2)c1ccc(O)cc1
T10
native IFP available
T10
dockmulti_91311c650f2e_T10
0.854 1.000 0.582 native_similarity final_rank_score -12.1824 -0.789216 14 3 Pose