FAIRMol

R-group Decomposition

Break a compound series into a common scaffold core and variable R-groups using RDKit R-group decomposition.

200 compounds 12 decomposed ← Tools
Detected Core
[#6]1:&@[#6]:&@[#6]2:&@[#6](:&@[#6]:&@[#6]:&@1)-&@[#6,#7,#16]-&@[#6]-&@[#6](-&@[#8]-&@2)-&!@[#6]1:&@[#6,#7,#8,#16]:&@[#7,#6](:&@[#7]:&@[#7,#8]:&@1)-&!@[#6&!R]-&!@[#6&!R]-&!@[#6]1:&@[#6]:&@[#6]:&@[#6]:&@[#6]:&@[#6]:&@1
R1 R2 R3 R4 R5 R6 R7 R8 R9
Auto-core fallback: MCS fallback from largest generic family (family n=10).
Tried 11 candidate core(s); selected generic_family_mcs.
188 compound(s) did not match the core and were excluded.
ID Structure Name Core R1 R2 R3 R4 R5 R6 R7 R8 R9
3
c1c(CCn2cc(C3([*:4])CC([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)nn2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
[H][*:5]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
23
c1c(CCc2noc(C3([*:4])CC([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)n2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
[H][*:5]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
29
c1c(CCn2cc(C3([*:4])CC([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)nn2)cc([*:3])c([*:2])c1[*:1]
O[*:1]
[H][*:2]
O[*:3]
C[*:4]
[H][*:5]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
59
c1c(CCc2nnc(C3([*:4])CC([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)s2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
[H][*:5]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
64
c1c(CCc2nnc(C3([*:4])CSc4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)o2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
66
c1c(CCn2cc(C3([*:4])CSc4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)nn2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
70
c1c(CCn2cc(C3([*:4])CN([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)nn2)cc([*:3])c([*:2])c1[*:1]
O[*:1]
[H][*:2]
O[*:3]
C[*:4]
[H][*:5]
[H][*:6]
C[*:7]
C[*:8]
C[*:9]
77
c1c(CCc2nnc(C3([*:4])CSc4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)o2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
CO[*:2]
CO[*:3]
C[*:4]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
107
c1c(CCc2noc(C3([*:4])CSc4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)n2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
111
c1c(CCc2nnc(C3([*:4])CC([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)o2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
[H][*:5]
O[*:6]
C[*:7]
C[*:8]
C[*:9]
133
c1c(CCn2cc(C3([*:4])CN([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)nn2)cc([*:3])c([*:2])c1[*:1]
[H][*:1]
O[*:2]
O[*:3]
C[*:4]
[H][*:5]
Oc1cccc([*:6])c1
C[*:7]
C[*:8]
C[*:9]
142
c1c(CCn2cc(C3([*:4])CN([*:5])c4c(c([*:8])c([*:9])c([*:6])c4[*:7])O3)nn2)cc([*:3])c([*:2])c1[*:1]
O[*:1]
[H][*:2]
O[*:3]
C[*:4]
Oc1ccc(C[*:5])cc1
[H][*:6]
C[*:7]
C[*:8]
C[*:9]
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