FAIRMol

TC265

Pose ID 16170 Compound 1981 Pose 973

DB Docking_panel_21Docking pose analysis is being read from this database.
Molecular metrics status: queued
Pose metrics recompute is queued in the background.
Metrics cached · SASA missing
T09
Bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) likely Leishmania major / Leishmania sp. homology model

3D complex viewer

Strict H-bonds Permissive H-bonds
Viewer legend
Protein receptor
Pocket residues
Cofactor context
Docked ligand
Overall assessment
Reject No SASA yet
Promising but geometrically suspicious
Binding strong Geometry low Native strong SASA missing
Strain ΔE
63.3 kcal/mol
Protein clashes
8
Internal clashes
9
Native overlap
contact recall 0.62, Jaccard 0.52, H-bond role recall 0.33
Burial
82%
Reason: 9 internal clashes, strain 63.3 kcal/mol
strain ΔE 63.3 kcal/mol 8 protein-contact clashes 9 intramolecular clashes

Interaction summary

HB 5 HY 24 PI 0 CLASH 0
Final rank7.208Score-18.543
Inter norm-0.386Intra norm0.043
Top1000noExcludedno
Contacts17H-bonds5
Artifact reasongeometry warning; 9 clashes; 8 protein contact clashes; high strain Δ 63.3
Residues
NDP301 ARG48 ARG97 GLY157 ILE45 LEU94 LYS57 MET53 PHE56 PHE91 PRO50 SER44 SER86 THR83 TRP47 VAL156 VAL87

Protein summary

511 residues
Protein targetT09Atoms8170
Residues511Chains2
Residue summaryLEU:1064; ARG:840; LYS:572; GLU:570; VAL:528; PHE:460; ILE:456; ALA:440; PRO:420; THR:406; TYR:357; ASP:312; GLN:289; ASN:238; SER:231; GLY:224

Receptor context

1 kept / 0 excluded
Receptor context filtering: interactions and SASA are computed against protein atoms plus allowed cofactors/ions. Native ligand-like HETATM partners are excluded from scoring.
Kept context 1 Excluded HETATM 0
Kept cofactors / ions
A:NDP301

Native ligand reference

★ reference
Interaction fingerprint calculated directly from the uploaded native ligand without docking. Current H-bond mode: strict.
Name3CL9Contacts21
PoseOpen native poseHB0
IFP residues
NDP301 ALA32 ARG97 ASP52 GLY157 ILE45 LEU94 LYS57 MET53 PHE55 PHE56 PHE91 PRO88 SER86 THR180 THR83 TYR162 VAL156 VAL30 VAL31 VAL87
Current overlap13Native recall0.62
Jaccard0.52RMSD-
HB strict2Strict recall0.29
HB same residue+role2HB role recall0.33
HB same residue2HB residue recall0.33

HB · H-bonds

Mode: strict. Count shows atom-level H-bonds; unique residues in summary: 0.

PI · π–π interactions

No pi · π–π interactions detected for this pose.

HY · Hydrophobic contacts

CLASH · Clashes

No clash · clashes detected for this pose.

All stored poses for this docking hit

PoseFinal rankInter normScoreHBCTCT overlapCT recallHB role rec.RMSDExcluded
973 7.2075579022657745 -0.386245 -18.5427 5 17 13 0.62 0.33 - no Current
978 8.291247358356513 -0.324707 -13.6078 6 19 12 0.57 0.33 - yes Open
979 9.46553711983882 -0.414234 -15.8062 5 21 13 0.62 0.50 - yes Open
974 57.979206133404986 -0.322155 -9.23307 8 19 12 0.57 0.33 - yes Open
972 58.983504081070535 -0.254423 -4.61141 8 16 11 0.52 0.33 - yes Open
977 60.44583651228716 -0.479431 -15.781 9 22 15 0.71 0.33 - yes Open
976 60.80063555141852 -0.293381 -5.12928 4 16 9 0.43 0.17 - yes Open
975 60.92412174325307 -0.306904 -6.72299 4 20 14 0.67 0.17 - yes Open

Molecular metrics

RDKit SASA burial, strain energy (MMFF94s), ligand efficiency and fit quality for this docking pose.
⚠ Not yet computed
Molecular metrics have not been computed for this pose yet. This page now reads only cached values; use a background recompute when you want fresh metrics without slowing the UI.