FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T10T11T21T22
ulfkktlib_626 0.950 0.889 5 0.83 0.95 0.89 0.91 0.86

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_626 T10
native IFP available
T10
selection_import_t10
0.950 1.000 0.856 native_similarity final_rank_score -19.7669 -1.21769 17 14 Pose
ulfkktlib_626 T21
native IFP available
T21
selection_import_t21
0.914 1.000 0.753 native_similarity final_rank_score -19.2148 -1.18465 14 12 Pose
ulfkktlib_626 T11
native IFP available
T11
selection_import_t11
0.889 1.000 0.683 native_similarity final_rank_score -22.1484 -1.1962 18 5 Pose
ulfkktlib_626 T22
native IFP available
T22
selection_import_t22
0.860 1.000 0.600 native_similarity final_rank_score -29.5046 -1.44555 15 11 Pose
ulfkktlib_626 T05
native IFP available
T05
selection_import_t05
0.832 1.000 0.521 native_similarity final_rank_score -21.776 -1.33289 14 3 Pose