FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T14T17T21
Z57281539 0.882 0.839 4 0.83 0.77 0.88 0.88

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57281539 T21
native IFP available
T21
selection_import_t21
0.882 1.000 0.663 native_similarity final_rank_score -25.8745 -1.26973 16 6 Pose
Z57281539 T17
native IFP available
T17
selection_import_t17
0.877 1.000 0.650 native_similarity final_rank_score -21.4419 -1.07823 11 4 Pose
Z57281539 T01
native IFP available
T01
selection_import_t01
0.826 1.000 0.503 native_similarity final_rank_score -24.7705 -1.27465 16 4 Pose
Z57281539 T14
native IFP available
T14
selection_import_t14
0.769 1.000 0.340 native_similarity final_rank_score -23.8267 -1.03864 12 6 Pose