FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 2 best compound-target hits listed 2 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T11T13
Z57170671
[H]N(Cc1ccccc1)c1ccc(S(=O)(=O)N([H])[H])cc1
0.903 0.891 2 0.90 0.88

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57170671
[H]N(Cc1ccccc1)c1ccc(S(=O)(=O)N([H])[H])cc1
T11
native IFP available
T11
selection_import_t11
0.903 1.000 0.723 native_similarity final_rank_score -24.4274 -1.38535 15 5 Pose
Z57170671
[H]N(Cc1ccccc1)c1ccc(S(=O)(=O)N([H])[H])cc1
T13
native IFP available
T13
selection_import_t13
0.878 1.000 0.652 native_similarity final_rank_score -30.5807 -1.82608 18 7 Pose