FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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3 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T07T21
Z56891524 0.898 0.898 1 0.90
Z56891524 0.881 0.881 1 0.88
Z56891524 0.793 0.793 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56891524 T21
native IFP available
T21
selection_import_t21
0.898 1.000 0.709 native_similarity final_rank_score -19.6137 -1.42911 14 7 Pose
Z56891524 T07
native IFP available
T07
selection_import_t07
0.881 1.000 0.659 native_similarity final_rank_score -31.3242 -1.72273 13 9 Pose
Z56891524 T03
native IFP available
T03
selection_import_t03
0.793 1.000 0.408 native_similarity final_rank_score -23.8801 -1.48264 15 7 Pose