FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T06T08T09T12T14T18T21
Z56838410 0.935 0.863 5 0.89 0.80 0.94 0.76 0.93
Z56838410 0.845 0.819 3 0.85 0.82 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56838410 T12
native IFP available
T12
selection_import_t12
0.935 1.000 0.816 native_similarity final_rank_score -27.3084 -1.05463 18 8 Pose
Z56838410 T21
native IFP available
T21
selection_import_t21
0.934 1.000 0.812 native_similarity final_rank_score -21.6 -1.0084 15 9 Pose
Z56838410 T08
native IFP available
T08
selection_import_t08
0.887 1.000 0.677 native_similarity final_rank_score -30.2501 -1.22359 16 7 Pose
Z56838410 T05
native IFP available
T05
selection_import_t05
0.845 1.000 0.558 native_similarity final_rank_score -24.7464 -1.12256 15 5 Pose
Z56838410 T06
native IFP available
T06
selection_import_t06
0.823 1.000 0.495 native_similarity final_rank_score -24.4022 -0.988078 19 1 Pose
Z56838410 T09
native IFP available
T09
selection_import_t09
0.798 1.000 0.424 native_similarity final_rank_score -27.7841 -1.09264 18 6 Pose
Z56838410 T14
native IFP available
T14
selection_import_t14
0.787 1.000 0.392 native_similarity final_rank_score -21.5725 -0.885262 14 8 Pose
Z56838410 T18
native IFP available
T18
selection_import_t18
0.758 1.000 0.309 native_similarity final_rank_score -17.4074 -0.813697 13 5 Pose