FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T16T17T20
Z56778002 0.883 0.827 3 0.73 0.87 0.88

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56778002 T20
native IFP available
T20
selection_import_t20
0.883 1.000 0.666 native_similarity final_rank_score -19.8922 -0.525751 15 4 Pose
Z56778002 T17
native IFP available
T17
selection_import_t17
0.872 1.000 0.633 native_similarity final_rank_score -18.9238 -0.63601 20 8 Pose
Z56778002 T16
native IFP available
T16
selection_import_t16
0.726 1.000 0.216 native_similarity final_rank_score -18.0133 -0.625381 15 5 Pose