FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T04T09T11T14
Z56773052 0.858 0.828 3 0.84 0.86 0.79
Z56773052 0.826 0.819 2 0.83 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56773052 T11
native IFP available
T11
selection_import_t11
0.858 1.000 0.594 native_similarity final_rank_score -21.8276 -0.85316 16 3 Pose
Z56773052 T09
native IFP available
T09
selection_import_t09
0.837 1.000 0.535 native_similarity final_rank_score -16.18 -0.912214 20 4 Pose
Z56773052 T03
native IFP available
T03
selection_import_t03
0.826 1.000 0.503 native_similarity final_rank_score -17.416 -0.957989 14 4 Pose
Z56773052 T04
native IFP available
T04
selection_import_t04
0.813 1.000 0.465 native_similarity final_rank_score -23.7852 -0.924931 11 1 Pose
Z56773052 T14
native IFP available
T14
selection_import_t14
0.789 1.000 0.398 native_similarity final_rank_score -21.2429 -0.780922 11 6 Pose