FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T05T06T08T10T12T14T16T17T19T21
Z49891479 0.868 0.806 3 0.77 0.78 0.87
Z49891479 0.867 0.793 8 0.79 0.85 0.87 0.81 0.73 0.71 0.71 0.87

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49891479 T12
native IFP available
T12
selection_import_t12
0.868 1.000 0.624 native_similarity final_rank_score -26.8947 -1.14179 17 7 Pose
Z49891479 T21
native IFP available
T21
selection_import_t21
0.867 1.000 0.619 native_similarity final_rank_score -22.8206 -1.01619 15 8 Pose
Z49891479 T10
native IFP available
T10
selection_import_t10
0.866 1.000 0.618 native_similarity final_rank_score -22.0827 -1.06385 14 10 Pose
Z49891479 T05
native IFP available
T05
selection_import_t05
0.850 1.000 0.571 native_similarity final_rank_score -29.6559 -1.19736 14 6 Pose
Z49891479 T14
native IFP available
T14
selection_import_t14
0.814 1.000 0.468 native_similarity final_rank_score -19.4208 -0.948948 12 7 Pose
Z49891479 T02
native IFP available
T02
selection_import_t02
0.788 1.000 0.393 native_similarity final_rank_score -28.4398 -1.07605 15 4 Pose
Z49891479 T08
native IFP available
T08
selection_import_t08
0.782 1.000 0.377 native_similarity final_rank_score -26.4874 -1.32189 16 6 Pose
Z49891479 T06
native IFP available
T06
selection_import_t06
0.769 1.000 0.340 native_similarity final_rank_score -17.9721 -0.972095 14 1 Pose
Z49891479 T16
native IFP available
T16
selection_import_t16
0.735 1.000 0.243 native_similarity final_rank_score -19.4317 -0.963412 10 4 Pose
Z49891479 T19
native IFP available
T19
selection_import_t19
0.714 1.000 0.183 native_similarity final_rank_score -31.1352 -1.3172 15 5 Pose
Z49891479 T17
native IFP available
T17
selection_import_t17
0.713 1.000 0.180 native_similarity final_rank_score -20.7043 -0.99865 12 3 Pose