FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T07T09T10T14
Z49580011 0.890 0.870 2 0.85 0.89
Z49580011 0.802 0.771 3 0.80 0.78 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49580011 T10
native IFP available
T10
selection_import_t10
0.890 1.000 0.686 native_similarity final_rank_score -22.9624 -1.03653 14 7 Pose
Z49580011 T07
native IFP available
T07
selection_import_t07
0.851 1.000 0.573 native_similarity final_rank_score -26.7345 -1.35382 15 5 Pose
Z49580011 T06
native IFP available
T06
selection_import_t06
0.802 1.000 0.433 native_similarity final_rank_score -21.5511 -1.07708 17 2 Pose
Z49580011 T09
native IFP available
T09
selection_import_t09
0.784 1.000 0.383 native_similarity final_rank_score -26.8681 -1.18314 15 7 Pose
Z49580011 T14
native IFP available
T14
selection_import_t14
0.727 1.000 0.220 native_similarity final_rank_score -23.075 -1.0033 9 5 Pose