FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T07T10T15T18T21
Z49536372 0.899 0.823 6 0.84 0.81 0.74 0.90 0.76 0.90
Z49536372 0.893 0.826 2 0.89 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49536372 T21
native IFP available
T21
selection_import_t21
0.899 1.000 0.711 native_similarity final_rank_score -21.1829 -1.16858 15 9 Pose
Z49536372 T07
native IFP available
T07
selection_import_t07
0.896 1.000 0.703 native_similarity final_rank_score -32.313 -1.58204 17 7 Pose
Z49536372 T10
native IFP available
T10
selection_import_t10
0.893 1.000 0.695 native_similarity final_rank_score -22.0598 -1.27189 14 8 Pose
Z49536372 T01
native IFP available
T01
selection_import_t01
0.837 1.000 0.533 native_similarity final_rank_score -24.1456 -1.2373 16 5 Pose
Z49536372 T02
native IFP available
T02
selection_import_t02
0.813 1.000 0.467 native_similarity final_rank_score -26.0025 -1.23635 14 3 Pose
Z49536372 T18
native IFP available
T18
selection_import_t18
0.758 1.000 0.309 native_similarity final_rank_score -16.3854 -0.993597 13 6 Pose
Z49536372 T15
native IFP available
T15
selection_import_t15
0.756 1.000 0.302 native_similarity final_rank_score -20.0049 -1.17195 14 4 Pose
Z49536372 T03
native IFP available
T03
selection_import_t03
0.739 1.000 0.254 native_similarity final_rank_score -25.547 -1.30138 9 6 Pose