FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T10T14
Z363947412 0.846 0.846 1 0.85
Z363947412 0.838 0.797 2 0.84 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z363947412 T10
native IFP available
T10
selection_import_t10
0.846 1.000 0.561 native_similarity final_rank_score -25.4105 -0.988525 15 8 Pose
Z363947412 T06
native IFP available
T06
selection_import_t06
0.838 1.000 0.539 native_similarity final_rank_score -21.5771 -0.91712 19 0 Pose
Z363947412 T14
native IFP available
T14
selection_import_t14
0.755 1.000 0.300 native_similarity final_rank_score -21.1808 -0.854229 12 4 Pose