FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T12T15
Z32440330 0.919 0.845 2 0.77 0.92
Z32440330 0.834 0.798 2 0.83 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z32440330 T12
native IFP available
T12
selection_import_t12
0.919 1.000 0.770 native_similarity final_rank_score -22.8932 -0.843316 20 8 Pose
Z32440330 T01
native IFP available
T01
selection_import_t01
0.834 1.000 0.524 native_similarity final_rank_score -25.0298 -0.730133 18 2 Pose
Z32440330 T03
native IFP available
T03
selection_import_t03
0.771 1.000 0.345 native_similarity final_rank_score -26.7164 -0.933124 13 6 Pose
Z32440330 T15
native IFP available
T15
selection_import_t15
0.763 1.000 0.324 native_similarity final_rank_score -24.2711 -0.716019 18 3 Pose