FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T13T18T22
Z30932232 0.878 0.824 3 0.88 0.76 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30932232 T13
native IFP available
T13
selection_import_t13
0.878 1.000 0.651 native_similarity final_rank_score -31.3899 -1.66211 22 8 Pose
Z30932232 T22
native IFP available
T22
selection_import_t22
0.839 1.000 0.539 native_similarity final_rank_score -33.9756 -1.73241 16 13 Pose
Z30932232 T18
native IFP available
T18
selection_import_t18
0.756 1.000 0.302 native_similarity final_rank_score -19.5556 -1.03253 14 7 Pose