FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T05T14T16T17
Z30879796 0.840 0.802 5 0.84 0.82 0.79 0.76 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30879796 T02
native IFP available
T02
selection_import_t02
0.840 1.000 0.544 native_similarity final_rank_score -24.5451 -0.810768 18 5 Pose
Z30879796 T05
native IFP available
T05
selection_import_t05
0.815 1.000 0.472 native_similarity final_rank_score -27.0054 -0.880427 15 2 Pose
Z30879796 T17
native IFP available
T17
selection_import_t17
0.807 1.000 0.450 native_similarity final_rank_score -21.7347 -0.702435 18 3 Pose
Z30879796 T14
native IFP available
T14
selection_import_t14
0.791 1.000 0.404 native_similarity final_rank_score -18.9361 -0.694543 16 3 Pose
Z30879796 T16
native IFP available
T16
selection_import_t16
0.756 1.000 0.302 native_similarity final_rank_score -23.1313 -0.715524 17 0 Pose