FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T09T14T16T17T20
Z30879401 0.922 0.833 5 0.90 0.79 0.78 0.78 0.92

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30879401 T20
native IFP available
T20
selection_import_t20
0.922 1.000 0.778 native_similarity final_rank_score -19.2224 -0.62049 12 6 Pose
Z30879401 T09
native IFP available
T09
selection_import_t09
0.896 1.000 0.702 native_similarity final_rank_score -24.9157 -0.821197 18 4 Pose
Z30879401 T14
native IFP available
T14
selection_import_t14
0.793 1.000 0.408 native_similarity final_rank_score -23.5334 -0.718914 10 4 Pose
Z30879401 T16
native IFP available
T16
selection_import_t16
0.779 1.000 0.368 native_similarity final_rank_score -20.5292 -0.743418 15 1 Pose
Z30879401 T17
native IFP available
T17
selection_import_t17
0.776 1.000 0.360 native_similarity final_rank_score -21.2854 -0.720981 16 2 Pose