FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T09T10T11T12T14T19T20
Z28654383 0.901 0.879 4 0.85 0.90 0.90 0.87
Z28654383 0.812 0.774 5 0.79 0.75 0.79 0.74 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z28654383 T10
native IFP available
T10
selection_import_t10
0.901 1.000 0.716 native_similarity final_rank_score -18.6569 -0.741272 16 9 Pose
Z28654383 T11
native IFP available
T11
selection_import_t11
0.897 1.000 0.705 native_similarity final_rank_score -24.4787 -0.811457 17 4 Pose
Z28654383 T12
native IFP available
T12
selection_import_t12
0.868 1.000 0.622 native_similarity final_rank_score -37.6491 -0.870253 14 12 Pose
Z28654383 T09
native IFP available
T09
selection_import_t09
0.849 1.000 0.569 native_similarity final_rank_score -35.2038 -0.877524 17 3 Pose
Z28654383 T20
native IFP available
T20
selection_import_t20
0.812 1.000 0.463 native_similarity final_rank_score -18.6285 -0.584181 13 3 Pose
Z28654383 T01
native IFP available
T01
selection_import_t01
0.788 1.000 0.394 native_similarity final_rank_score -31.297 -0.881199 17 4 Pose
Z28654383 T14
native IFP available
T14
selection_import_t14
0.786 1.000 0.390 native_similarity final_rank_score -26.6323 -0.692476 18 7 Pose
Z28654383 T03
native IFP available
T03
selection_import_t03
0.745 1.000 0.273 native_similarity final_rank_score -23.2831 -0.867463 13 3 Pose
Z28654383 T19
native IFP available
T19
selection_import_t19
0.739 1.000 0.255 native_similarity final_rank_score -36.752 -1.00306 22 6 Pose