FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T06T21
Z28270217 0.889 0.861 3 0.81 0.88 0.89

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z28270217 T21
native IFP available
T21
selection_import_t21
0.889 1.000 0.684 native_similarity final_rank_score -26.4433 -1.02566 17 6 Pose
Z28270217 T06
native IFP available
T06
selection_import_t06
0.880 1.000 0.657 native_similarity final_rank_score -19.646 -0.933482 18 2 Pose
Z28270217 T02
native IFP available
T02
selection_import_t02
0.812 1.000 0.464 native_similarity final_rank_score -26.4873 -1.01866 18 2 Pose