FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T05T11
Z20253414 0.886 0.850 3 0.81 0.85 0.89

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z20253414 T11
native IFP available
T11
selection_import_t11
0.886 1.000 0.676 native_similarity final_rank_score -25.92 -0.911876 13 6 Pose
Z20253414 T05
native IFP available
T05
selection_import_t05
0.850 1.000 0.571 native_similarity final_rank_score -27.2601 -1.0687 14 5 Pose
Z20253414 T01
native IFP available
T01
selection_import_t01
0.812 1.000 0.464 native_similarity final_rank_score -27.6012 -1.00883 18 5 Pose