FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T09T19T20
Z19574276 0.831 0.786 4 0.83 0.78 0.74 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z19574276 T04
native IFP available
T04
selection_import_t04
0.831 1.000 0.516 native_similarity final_rank_score -24.6214 -0.907637 14 1 Pose
Z19574276 T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -21.9002 -0.703539 11 7 Pose
Z19574276 T09
native IFP available
T09
selection_import_t09
0.782 1.000 0.376 native_similarity final_rank_score -23.9627 -0.942434 16 5 Pose
Z19574276 T19
native IFP available
T19
selection_import_t19
0.738 1.000 0.253 native_similarity final_rank_score -32.7619 -1.14768 23 7 Pose