FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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7 compounds in matrix 15 best compound-target hits listed 15 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T06T07T08T10T12T13T14T15T17T18T21T22
TC322 0.932 0.932 1 0.93
TC322 0.927 0.852 4 0.78 0.81 0.93 0.89
TC322 0.921 0.888 2 0.86 0.92
TC322 0.878 0.878 1 0.88
TC322 0.866 0.850 2 0.83 0.87
TC322 0.858 0.831 3 0.86 0.83 0.80
TC322 0.809 0.802 2 0.80 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC322 T12
native IFP available
T12
selection_import_t12
0.932 1.000 0.805 native_similarity final_rank_score -25.1959 -0.996019 17 11 Pose
TC322 T21
native IFP available
T21
selection_import_t21
0.927 1.000 0.793 native_similarity final_rank_score -21.7398 -0.842945 16 14 Pose
TC322 T10
native IFP available
T10
selection_import_t10
0.921 1.000 0.774 native_similarity final_rank_score -20.7891 -0.825681 18 11 Pose
TC322 T22
native IFP available
T22
selection_import_t22
0.891 1.000 0.689 native_similarity final_rank_score -26.7174 -0.994833 25 8 Pose
TC322 T13
native IFP available
T13
selection_import_t13
0.878 1.000 0.651 native_similarity final_rank_score -20.0049 -0.89117 22 8 Pose
TC322 T08
native IFP available
T08
selection_import_t08
0.866 1.000 0.618 native_similarity final_rank_score -22.7242 -0.995215 19 8 Pose
TC322 T07
native IFP available
T07
selection_import_t07
0.858 1.000 0.596 native_similarity final_rank_score -25.8237 -1.03118 17 7 Pose
TC322 T02
native IFP available
T02
selection_import_t02
0.855 1.000 0.586 native_similarity final_rank_score -22.9243 -0.798842 20 7 Pose
TC322 T01
native IFP available
T01
selection_import_t01
0.834 1.000 0.524 native_similarity final_rank_score -24.283 -0.807286 18 5 Pose
TC322 T14
native IFP available
T14
selection_import_t14
0.832 1.000 0.520 native_similarity final_rank_score -14.7614 -0.759554 15 8 Pose
TC322 T18
native IFP available
T18
selection_import_t18
0.813 1.000 0.465 native_similarity final_rank_score -15.7003 -0.666612 10 6 Pose
TC322 T15
native IFP available
T15
selection_import_t15
0.809 1.000 0.453 native_similarity final_rank_score -21.6564 -0.771498 15 7 Pose
TC322 T17
native IFP available
T17
selection_import_t17
0.802 1.000 0.433 native_similarity final_rank_score -22.3592 -0.785464 20 6 Pose
TC322 T06
native IFP available
T06
selection_import_t06
0.795 1.000 0.415 native_similarity final_rank_score -20.7484 -0.835843 19 2 Pose
TC322 T03
native IFP available
T03
selection_import_t03
0.777 1.000 0.363 native_similarity final_rank_score -19.8806 -0.906888 14 5 Pose