FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
Reset
13 compounds in matrix 56 best compound-target hits listed 20 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T04T05T06T07T08T09T10T11T12T13T14T15T16T17T18T19T20T22
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
0.957 0.884 9 0.91 0.85 0.86 0.86 0.91 0.96 0.88 0.78 0.95
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
0.944 0.847 6 0.83 0.85 0.83 0.93 0.69 0.94
KB_HAT_184
[H]N(c1ccc2c(c1)C(=O)OC2)c1nccc(-c2cnn3ncccc23)n1
0.922 0.832 4 0.83 0.92 0.82 0.76
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
0.908 0.825 10 0.84 0.86 0.82 0.81 0.84 0.91 0.82 0.80 0.78 0.77
KB_HAT_186
[H]N(CCCN([H])c1nc2ccsc2c(=O)n1[H])Cc1cc(Br)cc(Br)c1
0.890 0.842 2 0.89 0.79
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
0.877 0.841 6 0.84 0.86 0.82 0.88 0.84 0.80
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
0.865 0.818 6 0.79 0.86 0.84 0.80 0.80 0.81
KB_HAT_183
[H]N(C(C)=O)c1ccc(N([H])c2nccc(-c3cnn4ncccc34)n2)cc1C(F)(F)F
0.862 0.815 3 0.86 0.81 0.77
KB_HAT_18
[H]O[C@H]1CC[C@H](N([H])c2ncc(Cl)c(N([H])c3ccn4c3C(=O)N([H])CC4)n2)CC1
0.821 0.764 4 0.82 0.75 0.79 0.70
KB_HAT_185
[H]N([H])C(=Nc1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)N([H])[H]
0.808 0.794 2 0.81 0.78
KB_HAT_188
[H]N(CCC[N+]([H])([H])Cc1sc(Br)cc1C)c1cc(=O)c2ccccc2n1[H]
0.802 0.775 2 0.80 0.75
KB_HAT_189
[H]N(C[C@@H]1CCCCN1C(=O)c1cccc2ccccc12)C(=O)c1ccccc1
0.763 0.763 1 0.76
KB_HAT_189
[H]N(C[C@H]1CCCCN1C(=O)c1cccc2ccccc12)C(=O)c1ccccc1
0.733 0.733 1 0.73

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T10
native IFP available
T10
selection_import_t10
0.957 1.000 0.877 native_similarity final_rank_score -21.9275 -1.03292 16 13 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T22
native IFP available
T22
selection_import_t22
0.953 1.000 0.865 native_similarity final_rank_score -32.4281 -1.32151 23 13 Pose
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
T22
native IFP available
T22
selection_import_t22
0.944 1.000 0.840 native_similarity final_rank_score -32.0923 -1.26397 21 10 Pose
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
T10
native IFP available
T10
selection_import_t10
0.928 1.000 0.795 native_similarity final_rank_score -20.9441 -0.94287 14 9 Pose
KB_HAT_184
[H]N(c1ccc2c(c1)C(=O)OC2)c1nccc(-c2cnn3ncccc23)n1
T12
native IFP available
T12
selection_import_t12
0.922 1.000 0.777 native_similarity final_rank_score -24.433 -1.06174 18 10 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T12
native IFP available
T12
selection_import_t12
0.908 1.000 0.737 native_similarity final_rank_score -27.7545 -1.16369 18 7 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T09
native IFP available
T09
selection_import_t09
0.907 1.000 0.733 native_similarity final_rank_score -25.6628 -1.01508 16 7 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T01
native IFP available
T01
selection_import_t01
0.906 1.000 0.732 native_similarity final_rank_score -23.1832 -1.0168 18 5 Pose
KB_HAT_186
[H]N(CCCN([H])c1nc2ccsc2c(=O)n1[H])Cc1cc(Br)cc(Br)c1
T11
native IFP available
T11
selection_import_t11
0.890 1.000 0.685 native_similarity final_rank_score -25.4126 -1.15614 14 6 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T11
native IFP available
T11
selection_import_t11
0.881 1.000 0.659 native_similarity final_rank_score -18.0641 -0.980049 16 5 Pose
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
T09
native IFP available
T09
selection_import_t09
0.877 1.000 0.650 native_similarity final_rank_score -24.3289 -1.11276 18 4 Pose
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
T11
native IFP available
T11
selection_import_t11
0.865 1.000 0.613 native_similarity final_rank_score -18.1972 -0.998783 16 7 Pose
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
T02
native IFP available
T02
selection_import_t02
0.864 1.000 0.612 native_similarity final_rank_score -20.8724 -1.11735 18 2 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T08
native IFP available
T08
selection_import_t08
0.862 1.000 0.607 native_similarity final_rank_score -30.942 -1.34289 20 5 Pose
KB_HAT_183
[H]N(C(C)=O)c1ccc(N([H])c2nccc(-c3cnn4ncccc34)n2)cc1C(F)(F)F
T04
native IFP available
T04
selection_import_t04
0.862 1.000 0.605 native_similarity final_rank_score -22.331 -0.94498 14 5 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T05
native IFP available
T05
selection_import_t05
0.860 1.000 0.600 native_similarity final_rank_score -29.9812 -1.16496 12 11 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T05
native IFP available
T05
selection_import_t05
0.860 1.000 0.600 native_similarity final_rank_score -24.8275 -1.05791 12 7 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T04
native IFP available
T04
selection_import_t04
0.854 1.000 0.582 native_similarity final_rank_score -20.7112 -1.08422 12 3 Pose
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
T04
native IFP available
T04
selection_import_t04
0.854 1.000 0.582 native_similarity final_rank_score -21.076 -1.07441 12 3 Pose
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
T13
native IFP available
T13
selection_import_t13
0.845 1.000 0.557 native_similarity final_rank_score -22.9902 -1.05527 22 9 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T11
native IFP available
T11
selection_import_t11
0.842 1.000 0.548 native_similarity final_rank_score -20.3586 -0.921618 16 4 Pose
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
T01
native IFP available
T01
selection_import_t01
0.841 1.000 0.547 native_similarity final_rank_score -23.2936 -1.15872 16 3 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T02
native IFP available
T02
selection_import_t02
0.841 1.000 0.545 native_similarity final_rank_score -23.0809 -0.937703 20 2 Pose
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
T13
native IFP available
T13
selection_import_t13
0.836 1.000 0.531 native_similarity final_rank_score -23.9938 -1.17453 17 5 Pose
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
T02
native IFP available
T02
selection_import_t02
0.832 1.000 0.519 native_similarity final_rank_score -17.9228 -0.986253 17 2 Pose
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
T08
native IFP available
T08
selection_import_t08
0.830 1.000 0.514 native_similarity final_rank_score -31.3906 -1.32116 19 4 Pose
KB_HAT_184
[H]N(c1ccc2c(c1)C(=O)OC2)c1nccc(-c2cnn3ncccc23)n1
T04
native IFP available
T04
selection_import_t04
0.828 1.000 0.509 native_similarity final_rank_score -22.0823 -1.0853 13 4 Pose
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
T06
native IFP available
T06
selection_import_t06
0.825 1.000 0.499 native_similarity final_rank_score -22.6829 -1.13326 18 2 Pose
KB_HAT_18
[H]O[C@H]1CC[C@H](N([H])c2ncc(Cl)c(N([H])c3ccn4c3C(=O)N([H])CC4)n2)CC1
T04
native IFP available
T04
selection_import_t04
0.821 1.000 0.489 native_similarity final_rank_score -21.7702 -0.920154 13 5 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T06
native IFP available
T06
selection_import_t06
0.820 1.000 0.485 native_similarity final_rank_score -19.4943 -0.941489 20 2 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T14
native IFP available
T14
selection_import_t14
0.818 1.000 0.480 native_similarity final_rank_score -23.2836 -0.83535 14 3 Pose
KB_HAT_184
[H]N(c1ccc2c(c1)C(=O)OC2)c1nccc(-c2cnn3ncccc23)n1
T13
native IFP available
T13
selection_import_t13
0.817 1.000 0.478 native_similarity final_rank_score -23.6622 -1.19184 17 9 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T07
native IFP available
T07
selection_import_t07
0.813 1.000 0.465 native_similarity final_rank_score -30.2193 -1.13802 18 3 Pose
KB_HAT_183
[H]N(C(C)=O)c1ccc(N([H])c2nccc(-c3cnn4ncccc34)n2)cc1C(F)(F)F
T05
native IFP available
T05
selection_import_t05
0.810 1.000 0.457 native_similarity final_rank_score -28.5081 -0.962538 16 10 Pose
KB_HAT_185
[H]N([H])C(=Nc1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)N([H])[H]
T04
native IFP available
T04
selection_import_t04
0.808 1.000 0.452 native_similarity final_rank_score -22.1434 -0.946556 14 9 Pose
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
T18
native IFP available
T18
selection_import_t18
0.807 1.000 0.448 native_similarity final_rank_score -20.1478 -0.851435 11 6 Pose
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
T16
native IFP available
T16
selection_import_t16
0.804 1.000 0.440 native_similarity final_rank_score -22.1713 -0.921814 19 5 Pose
KB_HAT_188
[H]N(CCC[N+]([H])([H])Cc1sc(Br)cc1C)c1cc(=O)c2ccccc2n1[H]
T06
native IFP available
T06
selection_import_t06
0.802 1.000 0.433 native_similarity final_rank_score -22.3226 -1.01707 17 2 Pose
KB_HAT_186
[H]N(CCC[N+]([H])([H])Cc1cc(Br)cc(Br)c1)c1nc2ccsc2c(=O)n1[H]
T14
native IFP available
T14
selection_import_t14
0.801 1.000 0.432 native_similarity final_rank_score -18.037 -0.962226 14 8 Pose
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
T17
native IFP available
T17
selection_import_t17
0.800 1.000 0.428 native_similarity final_rank_score -21.24 -0.950138 21 5 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T15
native IFP available
T15
selection_import_t15
0.797 1.000 0.419 native_similarity final_rank_score -22.294 -0.881947 13 5 Pose
KB_HAT_186
[H]N(CCCN([H])c1nc2ccsc2c(=O)n1[H])Cc1cc(Br)cc(Br)c1
T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -13.1552 -0.846262 11 5 Pose
KB_HAT_18
[H]O[C@H]1CC[C@H](N([H])c2ncc(Cl)c(N([H])c3ccn4c3C(=O)N([H])CC4)n2)CC1
T18
native IFP available
T18
selection_import_t18
0.789 1.000 0.397 native_similarity final_rank_score -25.8828 -0.991054 15 8 Pose
KB_HAT_185
[H]N([H])C(N([H])c1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)=[N+]([H])[H]
T01
native IFP available
T01
selection_import_t01
0.788 1.000 0.394 native_similarity final_rank_score -26.4653 -1.18883 17 8 Pose
KB_HAT_181
[H]N(c1ccc(S(=O)(=O)N([H])[H])cc1)c1nccc(-c2cnn3ncccc23)n1
T18
native IFP available
T18
selection_import_t18
0.780 1.000 0.373 native_similarity final_rank_score -14.3909 -0.799775 12 4 Pose
KB_HAT_185
[H]N([H])C(=Nc1nc(-c2ccc(N([H])C(N([H])CC[N+]3([H])CCCC3)=[N+]([H])[H])cc2)cs1)N([H])[H]
T14
native IFP available
T14
selection_import_t14
0.780 1.000 0.372 native_similarity final_rank_score -15.3194 -0.857551 14 8 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T17
native IFP available
T17
selection_import_t17
0.779 1.000 0.369 native_similarity final_rank_score -19.122 -0.824677 22 4 Pose
KB_HAT_183
[H]N(C(C)=O)c1ccc(N([H])c2nccc(-c3cnn4ncccc34)n2)cc1C(F)(F)F
T14
native IFP available
T14
selection_import_t14
0.774 1.000 0.353 native_similarity final_rank_score -9.39962 -0.737854 13 8 Pose
KB_HAT_187
[H]N(CCC[N+]([H])([H])Cc1cn([H])c2ccc(Br)cc12)c1cc(=O)c2ccccc2n1[H]
T18
native IFP available
T18
selection_import_t18
0.774 1.000 0.353 native_similarity final_rank_score -24.4564 -0.939455 14 5 Pose
KB_HAT_189
[H]N(C[C@@H]1CCCCN1C(=O)c1cccc2ccccc12)C(=O)c1ccccc1
T16
native IFP available
T16
selection_import_t16
0.763 1.000 0.322 native_similarity final_rank_score -21.8279 -0.81807 14 3 Pose
KB_HAT_184
[H]N(c1ccc2c(c1)C(=O)OC2)c1nccc(-c2cnn3ncccc23)n1
T18
native IFP available
T18
selection_import_t18
0.761 1.000 0.317 native_similarity final_rank_score -15.1942 -0.795235 12 4 Pose
KB_HAT_188
[H]N(CCC[N+]([H])([H])Cc1sc(Br)cc1C)c1cc(=O)c2ccccc2n1[H]
T19
native IFP available
T19
selection_import_t19
0.749 1.000 0.283 native_similarity final_rank_score -26.8193 -1.28965 17 5 Pose
KB_HAT_18
[H]O[C@H]1CC[C@H](N([H])c2ncc(Cl)c(N([H])c3ccn4c3C(=O)N([H])CC4)n2)CC1
T15
native IFP available
T15
selection_import_t15
0.745 1.000 0.272 native_similarity final_rank_score -25.0514 -0.953717 11 6 Pose
KB_HAT_189
[H]N(C[C@H]1CCCCN1C(=O)c1cccc2ccccc12)C(=O)c1ccccc1
T19
native IFP available
T19
selection_import_t19
0.733 1.000 0.236 native_similarity final_rank_score -28.7613 -1.10756 20 4 Pose
KB_HAT_18
[H]O[C@H]1CC[C@H](N([H])c2ncc(Cl)c(N([H])c3ccn4c3C(=O)N([H])CC4)n2)CC1
T19
native IFP available
T19
selection_import_t19
0.701 1.000 0.146 native_similarity final_rank_score -35.2953 -1.28946 21 10 Pose
KB_HAT_182
[H]N(c1ccc(S(C)(=O)=O)cc1)c1nccc(-c2cnn3ncccc23)n1
T17
native IFP available
T17
selection_import_t17
0.694 1.000 0.125 native_similarity final_rank_score -18.545 -0.886047 15 6 Pose