FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB fairmolExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T06T09T11
KB_HAT_113 0.858 0.835 4 0.86 0.83 0.82 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
KB_HAT_113 T01
native IFP available
T01
selection_import_t01
0.858 1.000 0.595 native_similarity final_rank_score -21.6122 -1.04464 17 7 Pose
KB_HAT_113 T11
native IFP available
T11
selection_import_t11
0.839 1.000 0.539 native_similarity final_rank_score -16.0728 -1.02656 17 6 Pose
KB_HAT_113 T06
native IFP available
T06
selection_import_t06
0.825 1.000 0.500 native_similarity final_rank_score -19.1939 -1.06878 17 5 Pose
KB_HAT_113 T09
native IFP available
T09
selection_import_t09
0.817 1.000 0.478 native_similarity final_rank_score -22.1844 -1.02712 19 7 Pose