FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T06T08T11
ulfkktlib_1159 0.896 0.877 2 0.90 0.86
ulfkktlib_1159 0.854 0.854 1 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_1159 T06
native IFP available
T06
selection_import_t06
0.896 1.000 0.702 native_similarity final_rank_score -19.4265 -1.14631 18 6 Pose
ulfkktlib_1159 T08
native IFP available
T08
selection_import_t08
0.859 1.000 0.597 native_similarity final_rank_score -31.3513 -1.543 16 5 Pose
ulfkktlib_1159 T11
native IFP available
T11
selection_import_t11
0.854 1.000 0.583 native_similarity final_rank_score -19.9047 -1.17378 13 4 Pose