FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T06T17
ulfkktlib_1043 0.858 0.818 3 0.85 0.86 0.74

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
ulfkktlib_1043 T06
native IFP available
T06
selection_import_t06
0.858 1.000 0.593 native_similarity final_rank_score -19.8442 -1.12816 16 4 Pose
ulfkktlib_1043 T05
native IFP available
T05
selection_import_t05
0.852 1.000 0.578 native_similarity final_rank_score -25.8352 -1.41238 15 9 Pose
ulfkktlib_1043 T17
native IFP available
T17
selection_import_t17
0.743 1.000 0.264 native_similarity final_rank_score -21.5608 -1.10387 15 7 Pose