FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T12T13
Z85918290 0.899 0.856 3 0.81 0.90 0.86

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z85918290 T12
native IFP available
T12
selection_import_t12
0.899 1.000 0.712 native_similarity final_rank_score -29.5873 -1.41192 15 15 Pose
Z85918290 T13
native IFP available
T13
selection_import_t13
0.856 1.000 0.589 native_similarity final_rank_score -28.6412 -1.435 14 11 Pose
Z85918290 T04
native IFP available
T04
selection_import_t04
0.813 1.000 0.465 native_similarity final_rank_score -19.6294 -1.13671 11 2 Pose