FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 12 best compound-target hits listed 12 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T04T06T08T10T12T13T17T18T19T20T22
Z68348244 0.932 0.845 4 0.81 0.93 0.88 0.76
Z68348244 0.878 0.843 4 0.79 0.88 0.87 0.84
Z68348244 0.876 0.832 2 0.79 0.88
Z68348244 0.851 0.802 2 0.75 0.85

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z68348244 T12
native IFP available
T12
selection_import_t12
0.932 1.000 0.807 native_similarity final_rank_score -31.2454 -1.17421 19 10 Pose
Z68348244 T08
native IFP available
T08
selection_import_t08
0.878 1.000 0.651 native_similarity final_rank_score -31.8936 -1.22956 20 7 Pose
Z68348244 T13
native IFP available
T13
selection_import_t13
0.877 1.000 0.648 native_similarity final_rank_score -25.2594 -1.03276 21 9 Pose
Z68348244 T17
native IFP available
T17
selection_import_t17
0.876 1.000 0.645 native_similarity final_rank_score -18.6002 -0.822159 18 5 Pose
Z68348244 T10
native IFP available
T10
selection_import_t10
0.867 1.000 0.621 native_similarity final_rank_score -24.4835 -0.992764 15 9 Pose
Z68348244 T20
native IFP available
T20
selection_import_t20
0.851 1.000 0.574 native_similarity final_rank_score -19.7079 -0.776394 8 8 Pose
Z68348244 T22
native IFP available
T22
selection_import_t22
0.839 1.000 0.539 native_similarity final_rank_score -36.3056 -1.27709 23 6 Pose
Z68348244 T06
native IFP available
T06
selection_import_t06
0.812 1.000 0.464 native_similarity final_rank_score -16.984 -0.928176 18 3 Pose
Z68348244 T04
native IFP available
T04
selection_import_t04
0.788 1.000 0.394 native_similarity final_rank_score -21.4879 -0.891259 12 0 Pose
Z68348244 T03
native IFP available
T03
selection_import_t03
0.787 1.000 0.392 native_similarity final_rank_score -19.2662 -0.991632 12 3 Pose
Z68348244 T18
native IFP available
T18
selection_import_t18
0.758 1.000 0.309 native_similarity final_rank_score -19.5128 -0.81832 13 8 Pose
Z68348244 T19
native IFP available
T19
selection_import_t19
0.754 1.000 0.297 native_similarity final_rank_score -30.851 -1.14723 21 10 Pose