FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T04T06T12T18T19T22
Z57392960 0.865 0.791 4 0.76 0.76 0.79 0.86
Z57392960 0.859 0.790 4 0.79 0.86 0.79 0.72

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z57392960 T22
native IFP available
T22
selection_import_t22
0.865 1.000 0.613 native_similarity final_rank_score -33.5517 -1.28186 22 9 Pose
Z57392960 T12
native IFP available
T12
selection_import_t12
0.859 1.000 0.598 native_similarity final_rank_score -29.7471 -1.18227 15 10 Pose
Z57392960 T18
native IFP available
T18
selection_import_t18
0.793 1.000 0.408 native_similarity final_rank_score -30.0044 -0.828175 14 5 Pose
Z57392960 T06
native IFP available
T06
selection_import_t06
0.791 1.000 0.402 native_similarity final_rank_score -24.5341 -0.909194 16 1 Pose
Z57392960 T04
native IFP available
T04
selection_import_t04
0.787 1.000 0.392 native_similarity final_rank_score -28.1784 -1.08225 14 4 Pose
Z57392960 T01
native IFP available
T01
selection_import_t01
0.756 1.000 0.303 native_similarity final_rank_score -26.0129 -1.01949 14 4 Pose
Z57392960 T02
native IFP available
T02
selection_import_t02
0.756 1.000 0.303 native_similarity final_rank_score -25.3946 -0.987606 14 4 Pose
Z57392960 T19
native IFP available
T19
selection_import_t19
0.718 1.000 0.193 native_similarity final_rank_score -29.8201 -1.21241 18 9 Pose