FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T07T09T10T11T14T16T17T19T20T22
Z56574044 0.891 0.837 7 0.86 0.79 0.84 0.86 0.83 0.78 0.89
Z56574044 0.887 0.811 4 0.81 0.71 0.84 0.89

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z56574044 T17
native IFP available
T17
selection_import_t17
0.891 1.000 0.689 native_similarity final_rank_score -20.3873 -0.681281 19 6 Pose
Z56574044 T22
native IFP available
T22
selection_import_t22
0.887 1.000 0.678 native_similarity final_rank_score -29.1505 -0.873778 21 12 Pose
Z56574044 T03
native IFP available
T03
selection_import_t03
0.864 1.000 0.611 native_similarity final_rank_score -25.0673 -0.810999 20 1 Pose
Z56574044 T11
native IFP available
T11
selection_import_t11
0.863 1.000 0.608 native_similarity final_rank_score -19.5183 -0.696051 13 5 Pose
Z56574044 T10
native IFP available
T10
selection_import_t10
0.842 1.000 0.548 native_similarity final_rank_score -19.1628 -0.731554 12 12 Pose
Z56574044 T20
native IFP available
T20
selection_import_t20
0.840 1.000 0.542 native_similarity final_rank_score -17.2553 -0.535214 9 4 Pose
Z56574044 T14
native IFP available
T14
selection_import_t14
0.826 1.000 0.502 native_similarity final_rank_score -21.0256 -0.65471 17 6 Pose
Z56574044 T07
native IFP available
T07
selection_import_t07
0.809 1.000 0.454 native_similarity final_rank_score -28.254 -0.896433 14 2 Pose
Z56574044 T09
native IFP available
T09
selection_import_t09
0.790 1.000 0.399 native_similarity final_rank_score -25.164 -0.750608 18 4 Pose
Z56574044 T16
native IFP available
T16
selection_import_t16
0.782 1.000 0.378 native_similarity final_rank_score -19.7467 -0.720113 14 6 Pose
Z56574044 T19
native IFP available
T19
selection_import_t19
0.708 1.000 0.167 native_similarity final_rank_score -28.2135 -0.886001 22 6 Pose