FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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3 compounds in matrix 12 best compound-target hits listed 12 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T04T07T08T10T11T12T15T16T18T21T22
Z49613286 0.937 0.857 9 0.79 0.82 0.90 0.79 0.94 0.91 0.88 0.77 0.92
Z49613286 0.802 0.802 1 0.80
Z49613286 0.768 0.765 2 0.77 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49613286 T10
native IFP available
T10
selection_import_t10
0.937 1.000 0.820 native_similarity final_rank_score -39.0428 -1.25648 17 16 Pose
Z49613286 T21
native IFP available
T21
selection_import_t21
0.915 1.000 0.758 native_similarity final_rank_score -34.1919 -1.05347 16 9 Pose
Z49613286 T11
native IFP available
T11
selection_import_t11
0.909 1.000 0.740 native_similarity final_rank_score -26.7144 -0.993806 14 9 Pose
Z49613286 T07
native IFP available
T07
selection_import_t07
0.904 1.000 0.727 native_similarity final_rank_score -33.3711 -1.52839 20 10 Pose
Z49613286 T12
native IFP available
T12
selection_import_t12
0.881 1.000 0.661 native_similarity final_rank_score -28.772 -1.23305 19 12 Pose
Z49613286 T04
native IFP available
T04
selection_import_t04
0.816 1.000 0.474 native_similarity final_rank_score -25.444 -0.959116 12 4 Pose
Z49613286 T22
native IFP available
T22
selection_import_t22
0.802 1.000 0.435 native_similarity final_rank_score -37.8057 -1.31113 21 16 Pose
Z49613286 T03
native IFP available
T03
selection_import_t03
0.793 1.000 0.408 native_similarity final_rank_score -25.9422 -1.09542 15 8 Pose
Z49613286 T08
native IFP available
T08
selection_import_t08
0.787 1.000 0.392 native_similarity final_rank_score -41.4862 -1.45629 11 14 Pose
Z49613286 T18
native IFP available
T18
selection_import_t18
0.774 1.000 0.353 native_similarity final_rank_score -22.1082 -0.81173 14 8 Pose
Z49613286 T15
native IFP available
T15
selection_import_t15
0.768 1.000 0.337 native_similarity final_rank_score -30.2709 -1.1453 16 11 Pose
Z49613286 T16
native IFP available
T16
selection_import_t16
0.763 1.000 0.322 native_similarity final_rank_score -23.0462 -0.873483 14 11 Pose