FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
Reset
2 compounds in matrix 15 best compound-target hits listed 15 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T03T04T05T07T08T09T11T12T13T14T16T17T20T21
Z49606031 0.936 0.837 10 0.83 0.83 0.84 0.85 0.73 0.88 0.79 0.81 0.94 0.87
Z49606031 0.920 0.854 5 0.84 0.84 0.88 0.92 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49606031 T20
native IFP available
T20
selection_import_t20
0.936 1.000 0.817 native_similarity final_rank_score -19.3503 -0.718352 10 8 Pose
Z49606031 T12
native IFP available
T12
selection_import_t12
0.920 1.000 0.772 native_similarity final_rank_score -26.9388 -0.958986 15 11 Pose
Z49606031 T13
native IFP available
T13
selection_import_t13
0.876 1.000 0.647 native_similarity final_rank_score -28.0502 -1.04492 17 8 Pose
Z49606031 T11
native IFP available
T11
selection_import_t11
0.875 1.000 0.643 native_similarity final_rank_score -19.1381 -0.912384 16 5 Pose
Z49606031 T21
native IFP available
T21
selection_import_t21
0.872 1.000 0.633 native_similarity final_rank_score -29.8358 -0.867156 12 9 Pose
Z49606031 T05
native IFP available
T05
selection_import_t05
0.855 1.000 0.586 native_similarity final_rank_score -34.8672 -1.056 13 6 Pose
Z49606031 T07
native IFP available
T07
selection_import_t07
0.845 1.000 0.557 native_similarity final_rank_score -28.0046 -1.28326 21 7 Pose
Z49606031 T08
native IFP available
T08
selection_import_t08
0.841 1.000 0.547 native_similarity final_rank_score -23.8569 -1.17244 20 4 Pose
Z49606031 T04
native IFP available
T04
selection_import_t04
0.841 1.000 0.545 native_similarity final_rank_score -23.1601 -0.85723 14 3 Pose
Z49606031 T02
native IFP available
T02
selection_import_t02
0.834 1.000 0.524 native_similarity final_rank_score -29.8286 -0.909389 18 6 Pose
Z49606031 T03
native IFP available
T03
selection_import_t03
0.831 1.000 0.518 native_similarity final_rank_score -29.0925 -1.04528 14 3 Pose
Z49606031 T17
native IFP available
T17
selection_import_t17
0.811 1.000 0.460 native_similarity final_rank_score -35.251 -0.9827 16 7 Pose
Z49606031 T14
native IFP available
T14
selection_import_t14
0.789 1.000 0.398 native_similarity final_rank_score -19.9052 -0.790111 11 7 Pose
Z49606031 T16
native IFP available
T16
selection_import_t16
0.786 1.000 0.388 native_similarity final_rank_score -22.4444 -0.811178 13 7 Pose
Z49606031 T09
native IFP available
T09
selection_import_t09
0.733 1.000 0.237 native_similarity final_rank_score -28.7108 -1.08371 13 8 Pose