FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 11 best compound-target hits listed 11 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T06T07T08T09T11T12T15T16T19T22
Z49605089 0.929 0.880 2 0.83 0.93
Z49605089 0.926 0.875 3 0.93 0.91 0.79
Z49605089 0.889 0.806 5 0.79 0.89 0.73 0.75 0.87
Z49605089 0.751 0.751 1 0.75

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49605089 T12
native IFP available
T12
selection_import_t12
0.929 1.000 0.797 native_similarity final_rank_score -32.9951 -1.10874 19 11 Pose
Z49605089 T05
native IFP available
T05
selection_import_t05
0.926 1.000 0.790 native_similarity final_rank_score -26.6388 -0.967161 14 7 Pose
Z49605089 T08
native IFP available
T08
selection_import_t08
0.906 1.000 0.733 native_similarity final_rank_score -35.3217 -1.11671 15 7 Pose
Z49605089 T11
native IFP available
T11
selection_import_t11
0.889 1.000 0.683 native_similarity final_rank_score -24.2424 -0.884447 15 10 Pose
Z49605089 T22
native IFP available
T22
selection_import_t22
0.869 1.000 0.627 native_similarity final_rank_score -33.2396 -1.20946 19 11 Pose
Z49605089 T07
native IFP available
T07
selection_import_t07
0.831 1.000 0.518 native_similarity final_rank_score -31.0616 -1.05759 16 5 Pose
Z49605089 T09
native IFP available
T09
selection_import_t09
0.792 1.000 0.406 native_similarity final_rank_score -22.8409 -0.887105 17 6 Pose
Z49605089 T06
native IFP available
T06
selection_import_t06
0.791 1.000 0.402 native_similarity final_rank_score -23.177 -0.820122 16 4 Pose
Z49605089 T15
native IFP available
T15
selection_import_t15
0.751 1.000 0.289 native_similarity final_rank_score -23.0043 -0.857456 16 10 Pose
Z49605089 T19
native IFP available
T19
selection_import_t19
0.746 1.000 0.274 native_similarity final_rank_score -30.0286 -1.17956 21 7 Pose
Z49605089 T16
native IFP available
T16
selection_import_t16
0.733 1.000 0.236 native_similarity final_rank_score -18.3671 -0.788601 11 4 Pose