FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 3 best compound-target hits listed 3 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T16T21T22
Z49576315 0.945 0.838 2 0.73 0.94
Z49576315 0.935 0.935 1 0.93

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49576315 T21
native IFP available
T21
selection_import_t21
0.945 1.000 0.842 native_similarity final_rank_score -14.3269 -0.94732 18 16 Pose
Z49576315 T22
native IFP available
T22
selection_import_t22
0.935 1.000 0.813 native_similarity final_rank_score -32.2242 -1.3388 21 14 Pose
Z49576315 T16
native IFP available
T16
selection_import_t16
0.731 1.000 0.230 native_similarity final_rank_score -16.6015 -0.895289 12 8 Pose