FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T03T08T12T22
Z49565795 0.897 0.832 3 0.76 0.90 0.84
Z49565795 0.842 0.803 2 0.76 0.84

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49565795 T12
native IFP available
T12
selection_import_t12
0.897 1.000 0.705 native_similarity final_rank_score -27.9507 -1.01992 17 6 Pose
Z49565795 T22
native IFP available
T22
selection_import_t22
0.845 1.000 0.557 native_similarity final_rank_score -31.1956 -1.13327 21 5 Pose
Z49565795 T08
native IFP available
T08
selection_import_t08
0.842 1.000 0.549 native_similarity final_rank_score -33.4286 -1.18267 13 7 Pose
Z49565795 T03
native IFP available
T03
selection_import_t03
0.764 1.000 0.325 native_similarity final_rank_score -30.0659 -1.06732 10 4 Pose
Z49565795 T01
native IFP available
T01
selection_import_t01
0.756 1.000 0.303 native_similarity final_rank_score -26.0878 -0.985934 14 2 Pose