FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 16 best compound-target hits listed 16 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T04T05T07T08T09T10T11T12T14T16T18T19T20T21T22
Z49558975 0.963 0.848 10 0.76 0.82 0.86 0.83 0.85 0.94 0.75 0.80 0.96 0.91
Z49558975 0.909 0.909 1 0.91
Z49558975 0.873 0.775 3 0.87 0.71 0.74
Z49558975 0.816 0.815 2 0.82 0.81

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49558975 T21
native IFP available
T21
selection_import_t21
0.963 1.000 0.893 native_similarity final_rank_score -23.7588 -1.0456 16 12 Pose
Z49558975 T12
native IFP available
T12
selection_import_t12
0.943 1.000 0.837 native_similarity final_rank_score -29.6725 -1.29669 18 13 Pose
Z49558975 T10
native IFP available
T10
selection_import_t10
0.909 1.000 0.740 native_similarity final_rank_score -30.6516 -1.12297 15 12 Pose
Z49558975 T22
native IFP available
T22
selection_import_t22
0.907 1.000 0.735 native_similarity final_rank_score -30.6177 -1.35108 20 11 Pose
Z49558975 T11
native IFP available
T11
selection_import_t11
0.873 1.000 0.638 native_similarity final_rank_score -24.6432 -0.951518 18 7 Pose
Z49558975 T07
native IFP available
T07
selection_import_t07
0.863 1.000 0.609 native_similarity final_rank_score -27.9704 -1.17551 13 10 Pose
Z49558975 T09
native IFP available
T09
selection_import_t09
0.847 1.000 0.563 native_similarity final_rank_score -25.5677 -1.02422 16 8 Pose
Z49558975 T08
native IFP available
T08
selection_import_t08
0.835 1.000 0.528 native_similarity final_rank_score -37.7576 -1.3698 12 13 Pose
Z49558975 T05
native IFP available
T05
selection_import_t05
0.816 1.000 0.475 native_similarity final_rank_score -29.7786 -1.14659 11 7 Pose
Z49558975 T04
native IFP available
T04
selection_import_t04
0.816 1.000 0.474 native_similarity final_rank_score -30.545 -1.06732 12 4 Pose
Z49558975 T14
native IFP available
T14
selection_import_t14
0.814 1.000 0.468 native_similarity final_rank_score -22.6688 -1.02254 18 7 Pose
Z49558975 T20
native IFP available
T20
selection_import_t20
0.799 1.000 0.425 native_similarity final_rank_score -16.978 -0.924801 10 8 Pose
Z49558975 T03
native IFP available
T03
selection_import_t03
0.760 1.000 0.313 native_similarity final_rank_score -28.7896 -1.16836 12 10 Pose
Z49558975 T19
native IFP available
T19
selection_import_t19
0.750 1.000 0.285 native_similarity final_rank_score -29.0037 -1.26732 16 10 Pose
Z49558975 T18
native IFP available
T18
selection_import_t18
0.738 1.000 0.253 native_similarity final_rank_score -18.2129 -0.828194 14 9 Pose
Z49558975 T16
native IFP available
T16
selection_import_t16
0.714 1.000 0.184 native_similarity final_rank_score -20.4088 -1.07039 11 6 Pose