FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T07T08T10
Z49547268 0.865 0.849 3 0.84 0.84 0.87
Z49547268 0.750 0.750 1 0.75

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z49547268 T10
native IFP available
T10
selection_import_t10
0.865 1.000 0.615 native_similarity final_rank_score -30.8377 -1.17484 13 9 Pose
Z49547268 T07
native IFP available
T07
selection_import_t07
0.841 1.000 0.545 native_similarity final_rank_score -33.1942 -1.56773 15 6 Pose
Z49547268 T08
native IFP available
T08
selection_import_t08
0.841 1.000 0.545 native_similarity final_rank_score -32.1275 -1.50515 15 6 Pose
Z49547268 T03
native IFP available
T03
selection_import_t03
0.750 1.000 0.287 native_similarity final_rank_score -27.1626 -1.21278 10 6 Pose