FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T05T12T17T18T20T22
Z44848907 0.911 0.854 6 0.83 0.81 0.85 0.91 0.84 0.87
Z44848907 0.850 0.785 3 0.85 0.75 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44848907 T12
native IFP available
T12
selection_import_t12
0.911 1.000 0.747 native_similarity final_rank_score -33.8349 -0.787302 18 10 Pose
Z44848907 T22
native IFP available
T22
selection_import_t22
0.873 1.000 0.637 native_similarity final_rank_score -28.2644 -0.85151 26 7 Pose
Z44848907 T05
native IFP available
T05
selection_import_t05
0.852 1.000 0.578 native_similarity final_rank_score -26.296 -0.818739 15 2 Pose
Z44848907 T03
native IFP available
T03
selection_import_t03
0.850 1.000 0.571 native_similarity final_rank_score -24.416 -0.85465 16 3 Pose
Z44848907 T20
native IFP available
T20
selection_import_t20
0.841 1.000 0.546 native_similarity final_rank_score -19.2757 -0.598552 13 6 Pose
Z44848907 T01
native IFP available
T01
selection_import_t01
0.834 1.000 0.524 native_similarity final_rank_score -28.0767 -0.730944 18 3 Pose
Z44848907 T02
native IFP available
T02
selection_import_t02
0.812 1.000 0.462 native_similarity final_rank_score -17.4267 -0.72906 16 3 Pose
Z44848907 T18
native IFP available
T18
selection_import_t18
0.756 1.000 0.302 native_similarity final_rank_score -26.298 -0.600788 14 2 Pose
Z44848907 T17
native IFP available
T17
selection_import_t17
0.750 1.000 0.287 native_similarity final_rank_score -20.0039 -0.620927 20 5 Pose