FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 17 best compound-target hits listed 17 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T04T05T07T08T09T10T11T12T14T15T17T18T20T21T22
Z44848695 0.945 0.844 11 0.84 0.82 0.86 0.85 0.77 0.91 0.81 0.78 0.82 0.94 0.87
Z44848695 0.928 0.855 6 0.80 0.80 0.93 0.84 0.87 0.89

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z44848695 T20
native IFP available
T20
selection_import_t20
0.945 1.000 0.842 native_similarity final_rank_score -19.3192 -0.596559 9 4 Pose
Z44848695 T10
native IFP available
T10
selection_import_t10
0.928 1.000 0.795 native_similarity final_rank_score -21.5464 -0.987515 20 9 Pose
Z44848695 T12
native IFP available
T12
selection_import_t12
0.915 1.000 0.757 native_similarity final_rank_score -29.2758 -0.864096 18 8 Pose
Z44848695 T21
native IFP available
T21
selection_import_t21
0.887 1.000 0.678 native_similarity final_rank_score -23.7542 -0.763952 15 5 Pose
Z44848695 T17
native IFP available
T17
selection_import_t17
0.874 1.000 0.639 native_similarity final_rank_score -22.4551 -0.71896 19 5 Pose
Z44848695 T22
native IFP available
T22
selection_import_t22
0.868 1.000 0.623 native_similarity final_rank_score -36.8603 -1.05786 25 15 Pose
Z44848695 T07
native IFP available
T07
selection_import_t07
0.864 1.000 0.611 native_similarity final_rank_score -33.6375 -1.11002 17 6 Pose
Z44848695 T08
native IFP available
T08
selection_import_t08
0.849 1.000 0.568 native_similarity final_rank_score -32.4439 -0.991555 16 5 Pose
Z44848695 T01
native IFP available
T01
selection_import_t01
0.844 1.000 0.555 native_similarity final_rank_score -24.9832 -0.865383 19 3 Pose
Z44848695 T11
native IFP available
T11
selection_import_t11
0.841 1.000 0.547 native_similarity final_rank_score -19.6099 -0.749058 21 4 Pose
Z44848695 T02
native IFP available
T02
selection_import_t02
0.822 1.000 0.491 native_similarity final_rank_score -28.9271 -0.921659 15 3 Pose
Z44848695 T18
native IFP available
T18
selection_import_t18
0.818 1.000 0.481 native_similarity final_rank_score -23.5838 -0.680606 13 2 Pose
Z44848695 T14
native IFP available
T14
selection_import_t14
0.815 1.000 0.470 native_similarity final_rank_score -32.1977 -0.747623 16 7 Pose
Z44848695 T04
native IFP available
T04
selection_import_t04
0.803 1.000 0.437 native_similarity final_rank_score -20.976 -0.857079 16 6 Pose
Z44848695 T05
native IFP available
T05
selection_import_t05
0.799 1.000 0.426 native_similarity final_rank_score -31.76 -0.87546 13 6 Pose
Z44848695 T15
native IFP available
T15
selection_import_t15
0.777 1.000 0.362 native_similarity final_rank_score -22.0076 -0.737357 13 5 Pose
Z44848695 T09
native IFP available
T09
selection_import_t09
0.767 1.000 0.333 native_similarity final_rank_score -29.0159 -0.809808 15 2 Pose