FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T06T07T10T13T22
Z31408577 0.876 0.826 6 0.80 0.83 0.88 0.83 0.85 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z31408577 T07
native IFP available
T07
selection_import_t07
0.876 1.000 0.645 native_similarity final_rank_score -32.1541 -1.28409 18 6 Pose
Z31408577 T13
native IFP available
T13
selection_import_t13
0.852 1.000 0.577 native_similarity final_rank_score -27.6292 -1.11458 21 8 Pose
Z31408577 T10
native IFP available
T10
selection_import_t10
0.828 1.000 0.508 native_similarity final_rank_score -20.3387 -0.896016 11 7 Pose
Z31408577 T06
native IFP available
T06
selection_import_t06
0.827 1.000 0.507 native_similarity final_rank_score -19.1893 -0.835771 18 0 Pose
Z31408577 T04
native IFP available
T04
selection_import_t04
0.796 1.000 0.418 native_similarity final_rank_score -22.1367 -0.91201 11 2 Pose
Z31408577 T22
native IFP available
T22
selection_import_t22
0.777 1.000 0.362 native_similarity final_rank_score -28.8668 -1.13771 17 12 Pose