FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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4 compounds in matrix 15 best compound-target hits listed 15 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T04T08T09T11T14T15T16T17T18T19T20T21
Z31287542 0.895 0.779 7 0.81 0.89 0.75 0.73 0.75 0.73 0.79
Z31287542 0.863 0.863 1 0.86
Z31287542 0.837 0.807 2 0.84 0.78
Z31287542 0.826 0.783 5 0.78 0.79 0.83 0.76 0.76

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z31287542 T11
native IFP available
T11
selection_import_t11
0.895 1.000 0.699 native_similarity final_rank_score -23.0241 -0.737126 14 7 Pose
Z31287542 T21
native IFP available
T21
selection_import_t21
0.863 1.000 0.609 native_similarity final_rank_score -25.1488 -0.727699 15 8 Pose
Z31287542 T08
native IFP available
T08
selection_import_t08
0.837 1.000 0.533 native_similarity final_rank_score -34.1913 -1.00249 15 3 Pose
Z31287542 T03
native IFP available
T03
selection_import_t03
0.826 1.000 0.503 native_similarity final_rank_score -25.7247 -0.834785 14 4 Pose
Z31287542 T04
native IFP available
T04
selection_import_t04
0.809 1.000 0.454 native_similarity final_rank_score -28.691 -0.85907 12 2 Pose
Z31287542 T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -26.3588 -0.774059 11 6 Pose
Z31287542 T02
native IFP available
T02
selection_import_t02
0.791 1.000 0.402 native_similarity final_rank_score -27.3861 -0.809397 16 5 Pose
Z31287542 T14
native IFP available
T14
selection_import_t14
0.778 1.000 0.365 native_similarity final_rank_score -23.4308 -0.682309 15 4 Pose
Z31287542 T01
native IFP available
T01
selection_import_t01
0.777 1.000 0.363 native_similarity final_rank_score -25.2184 -0.758944 14 4 Pose
Z31287542 T18
native IFP available
T18
selection_import_t18
0.764 1.000 0.326 native_similarity final_rank_score -22.3023 -0.658059 11 5 Pose
Z31287542 T09
native IFP available
T09
selection_import_t09
0.756 1.000 0.303 native_similarity final_rank_score -23.7729 -0.76585 14 6 Pose
Z31287542 T15
native IFP available
T15
selection_import_t15
0.753 1.000 0.295 native_similarity final_rank_score -25.0111 -0.748134 15 5 Pose
Z31287542 T17
native IFP available
T17
selection_import_t17
0.750 1.000 0.287 native_similarity final_rank_score -23.089 -0.656537 20 1 Pose
Z31287542 T16
native IFP available
T16
selection_import_t16
0.731 1.000 0.230 native_similarity final_rank_score -25.6304 -0.729279 12 3 Pose
Z31287542 T19
native IFP available
T19
selection_import_t19
0.725 1.000 0.215 native_similarity final_rank_score -33.9929 -0.94457 19 6 Pose