FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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3 compounds in matrix 8 best compound-target hits listed 8 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T08T10T12T14T16T17T19
Z31277949 0.907 0.826 4 0.91 0.88 0.78 0.74
Z31277949 0.817 0.788 3 0.80 0.82 0.74
Z31277949 0.789 0.789 1 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z31277949 T10
native IFP available
T10
selection_import_t10
0.907 1.000 0.734 native_similarity final_rank_score -24.452 -0.742972 16 9 Pose
Z31277949 T12
native IFP available
T12
selection_import_t12
0.878 1.000 0.653 native_similarity final_rank_score -30.3279 -0.865903 18 9 Pose
Z31277949 T08
native IFP available
T08
selection_import_t08
0.817 1.000 0.478 native_similarity final_rank_score -31.9888 -1.01474 14 3 Pose
Z31277949 T03
native IFP available
T03
selection_import_t03
0.801 1.000 0.432 native_similarity final_rank_score -22.5635 -0.836469 17 3 Pose
Z31277949 T17
native IFP available
T17
selection_import_t17
0.789 1.000 0.396 native_similarity final_rank_score -23.2205 -0.789454 18 6 Pose
Z31277949 T14
native IFP available
T14
selection_import_t14
0.780 1.000 0.372 native_similarity final_rank_score -25.9236 -0.757051 14 6 Pose
Z31277949 T16
native IFP available
T16
selection_import_t16
0.745 1.000 0.270 native_similarity final_rank_score -24.7008 -0.733383 14 6 Pose
Z31277949 T19
native IFP available
T19
selection_import_t19
0.738 1.000 0.253 native_similarity final_rank_score -32.5853 -0.976493 20 9 Pose