FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T05T06T13T14
Z31204537 0.860 0.813 4 0.83 0.83 0.86 0.74

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z31204537 T13
native IFP available
T13
selection_import_t13
0.860 1.000 0.601 native_similarity final_rank_score -30.5321 -1.22342 13 11 Pose
Z31204537 T05
native IFP available
T05
selection_import_t05
0.827 1.000 0.506 native_similarity final_rank_score -31.4004 -1.21271 11 3 Pose
Z31204537 T06
native IFP available
T06
selection_import_t06
0.825 1.000 0.500 native_similarity final_rank_score -25.7013 -1.01265 17 1 Pose
Z31204537 T14
native IFP available
T14
selection_import_t14
0.741 1.000 0.260 native_similarity final_rank_score -25.1728 -1.06483 11 3 Pose