FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T02T05T11T17
Z30225126 0.848 0.843 2 0.84 0.85
Z30225126 0.822 0.787 2 0.82 0.75

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z30225126 T11
native IFP available
T11
selection_import_t11
0.848 1.000 0.565 native_similarity final_rank_score -22.7323 -0.850343 17 2 Pose
Z30225126 T02
native IFP available
T02
selection_import_t02
0.838 1.000 0.539 native_similarity final_rank_score -27.6808 -0.865085 19 2 Pose
Z30225126 T05
native IFP available
T05
selection_import_t05
0.822 1.000 0.490 native_similarity final_rank_score -26.9927 -0.969191 13 5 Pose
Z30225126 T17
native IFP available
T17
selection_import_t17
0.752 1.000 0.292 native_similarity final_rank_score -23.5134 -0.716238 19 5 Pose