FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T03T16T19T20
Z27434678 0.940 0.810 4 0.87 0.72 0.72 0.94

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z27434678 T20
native IFP available
T20
selection_import_t20
0.940 1.000 0.829 native_similarity final_rank_score -20.6299 -0.590614 14 5 Pose
Z27434678 T03
native IFP available
T03
selection_import_t03
0.866 1.000 0.618 native_similarity final_rank_score -26.2638 -0.912385 17 6 Pose
Z27434678 T16
native IFP available
T16
selection_import_t16
0.718 1.000 0.194 native_similarity final_rank_score -24.8764 -0.707293 9 5 Pose
Z27434678 T19
native IFP available
T19
selection_import_t19
0.716 1.000 0.188 native_similarity final_rank_score -28.7199 -1.01351 23 6 Pose