FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 4 best compound-target hits listed 4 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T12
Z18798950 0.938 0.838 4 0.79 0.79 0.83 0.94

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z18798950 T12
native IFP available
T12
selection_import_t12
0.938 1.000 0.824 native_similarity final_rank_score -21.6865 -0.857473 16 11 Pose
Z18798950 T03
native IFP available
T03
selection_import_t03
0.834 1.000 0.525 native_similarity final_rank_score -17.6134 -0.878902 16 4 Pose
Z18798950 T02
native IFP available
T02
selection_import_t02
0.791 1.000 0.402 native_similarity final_rank_score -23.0442 -0.871676 16 2 Pose
Z18798950 T01
native IFP available
T01
selection_import_t01
0.788 1.000 0.394 native_similarity final_rank_score -26.159 -0.807666 17 2 Pose