FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 9 best compound-target hits listed 9 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T04T05T06T09T10T13T14T17T21
Z16383985 0.926 0.875 4 0.86 0.80 0.92 0.93
Z16383985 0.926 0.843 5 0.89 0.74 0.93 0.87 0.78

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z16383985 T21
native IFP available
T21
selection_import_t21
0.926 1.000 0.790 native_similarity final_rank_score -25.2594 -0.926931 15 10 Pose
Z16383985 T10
native IFP available
T10
selection_import_t10
0.926 1.000 0.789 native_similarity final_rank_score -23.9874 -0.97996 16 10 Pose
Z16383985 T17
native IFP available
T17
selection_import_t17
0.916 1.000 0.761 native_similarity final_rank_score -20.3424 -0.825934 17 4 Pose
Z16383985 T04
native IFP available
T04
selection_import_t04
0.894 1.000 0.696 native_similarity final_rank_score -12.2021 -0.917555 14 7 Pose
Z16383985 T13
native IFP available
T13
selection_import_t13
0.871 1.000 0.630 native_similarity final_rank_score -22.1215 -0.987817 23 9 Pose
Z16383985 T05
native IFP available
T05
selection_import_t05
0.860 1.000 0.600 native_similarity final_rank_score -25.5436 -1.17604 16 7 Pose
Z16383985 T06
native IFP available
T06
selection_import_t06
0.798 1.000 0.424 native_similarity final_rank_score -21.2246 -0.832144 18 4 Pose
Z16383985 T14
native IFP available
T14
selection_import_t14
0.784 1.000 0.382 native_similarity final_rank_score -21.3582 -0.820251 15 9 Pose
Z16383985 T09
native IFP available
T09
selection_import_t09
0.743 1.000 0.267 native_similarity final_rank_score -25.578 -0.9349 14 4 Pose