FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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1 compounds in matrix 5 best compound-target hits listed 5 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T07T10T11T12T13
Z104497306 0.956 0.904 5 0.86 0.94 0.89 0.96 0.87

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
Z104497306 T12
native IFP available
T12
selection_import_t12
0.956 1.000 0.876 native_similarity final_rank_score -23.8017 -1.51719 18 14 Pose
Z104497306 T10
native IFP available
T10
selection_import_t10
0.940 1.000 0.829 native_similarity final_rank_score -18.6377 -1.47405 17 16 Pose
Z104497306 T11
native IFP available
T11
selection_import_t11
0.890 1.000 0.685 native_similarity final_rank_score -24.2473 -1.42438 14 5 Pose
Z104497306 T13
native IFP available
T13
selection_import_t13
0.870 1.000 0.630 native_similarity final_rank_score -25.3542 -1.92763 20 12 Pose
Z104497306 T07
native IFP available
T07
selection_import_t07
0.863 1.000 0.608 native_similarity final_rank_score -24.6391 -1.75178 16 12 Pose