FAIRMol

Reverse docking explorer

Search one compound across many targets or scan the strongest compound-target pairs in the active database. The combined reverse-docking score uses a normalized docking-score estimator together with an interaction-fingerprint component.

DB SELECTIONExplorer results are being read from this database.
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2 compounds in matrix 6 best compound-target hits listed 6 targets
• Combined reverse-docking score = 65% normalized docking-score estimator + 35% interaction-fingerprint component.
• When a native ligand exists for an experiment, the interaction-fingerprint component is driven by similarity to the native contact/H-bond pattern.
• When no native ligand exists, the interaction-fingerprint component falls back to contact richness within the experiment (normalized contacts and H-bonds).

Compounds × targets matrix

Each cell shows the best combined reverse-docking score found for that compound on that target. Blank cells mean no imported pose passed the current filters.
Compound Best Mean Targets T01T02T03T14T16T20
TC85 0.819 0.803 4 0.81 0.82 0.82 0.77
TC85 0.793 0.769 2 0.74 0.79

Best compound-target hits

The score column is the combined reverse-docking score. The next two columns expose its components: normalized score-estimator and interaction fingerprint.
CompoundTargetExperimentCombinedScore partIFP partIFP modeMetricDock scoreInter normContactsHB
TC85 T02
native IFP available
T02
selection_import_t02
0.819 1.000 0.484 native_similarity final_rank_score -28.0234 -0.804847 18 3 Pose
TC85 T03
native IFP available
T03
selection_import_t03
0.816 1.000 0.475 native_similarity final_rank_score -25.2363 -0.749322 19 2 Pose
TC85 T01
native IFP available
T01
selection_import_t01
0.809 1.000 0.454 native_similarity final_rank_score -28.9511 -0.847872 17 4 Pose
TC85 T20
native IFP available
T20
selection_import_t20
0.793 1.000 0.410 native_similarity final_rank_score -15.1544 -0.509009 11 4 Pose
TC85 T14
native IFP available
T14
selection_import_t14
0.769 1.000 0.340 native_similarity final_rank_score -19.6244 -0.60852 12 4 Pose
TC85 T16
native IFP available
T16
selection_import_t16
0.745 1.000 0.270 native_similarity final_rank_score -20.7392 -0.661471 14 3 Pose